Transcript 3600l25.ppt

Psychology 3600
Reciprocal Inhibition
LTP
Reciprocal Inhibition-Basic Network
Reciprocal Inhibition-Clione Swimming
Learning and Memory
Hebb’s Postulate:
“When an axon of cell A is near enough to
excite cell B and repeatedly or persistently
takes part in firing it, some growth process or
metabolic change takes place in one or both
cells such that A’s efficiency, as one of the cells
firing B, is increased”.
Hebbian Synaptic Rule
The Patient H.M.
H.M.
Control
Hippocampus
Hippocampus
Hippocampal Tri-synaptic Circuit
LTP Induction
LTP Measurement
Long-Term Potentiation
Long-Term Potentiation
Hebbian Principles of LTP
Hebbian Principles of LTP
Pre-Post Pairing
Bi-directional Coupling
Bi-directional Coupling
Glutamate Receptor Model of LTP
Glutamate Receptor Model of LTP
Before
After
Silent Synapse Model
Glutamate Receptor Model of LTP